[Effector peptides of the brain renin-angiotensin system in central mechanisms of learned and natural forms of drinking behavior in rats].

Central mechanisms of angiotensin involvement in initiation and realization of operant forms of drinking behavior were investigated. It was suggested that intracerebroventricular microinjection of angiotensin-II and angiotensin-IIl specifically affected the learned forms of drinking behavior. The experiments demonstrated that [des-Asp1]-angiotensin-I produced only the natural forms of drinking behavior. Angiotensins modulated specific forms of thirst-associated behavior such as exploring, grooming, and ingestive behavior. Injections of AT1 receptor antagonist losartan were associated with acute water intake decrease and sharp operant behavior inactivation.

[Comparative analysis of motivation-activated effects of angiotensins in rats]. / Sravnitel'nyi analyz motivatiogennoi aktivnosti angiotenzinov u krys v éksperimente.

The effects of angiotensin-II, angiotensin-III, and [des-Asp1-angiotensin-I on drinking and attendant behaviors of rats were studied. Special behavioral patterns were observed after intracerebroventricular administration of angiotensins. The nature and possible mechanisms of behavioral effects of peptidergic brain stimulation are discussed.

[Regulation by myelopid of immunoglobulin production in culture of human peripheral blood lymphocytes in normal and secondary immunodeficient state]. / Reguliatsiia mielopidom produktsii immunoglobulinov v kul'ture limfotsitov perifericheskoi krovi cheloveka v norme i pri vtorichnom immunodefitsitnom sostoianii.

The effect of myelopid (MP) on the in vitro antibody production in man in norm and secondary postoperative immunodeficiency state, as well as the effect of immunocorrection therapy with MP on PWM-induced antibody production in LPB cultures during postoperative period have been studied. A stimulating effect of MP on IgA and IgM production in LPB cultures on the 8th day after an operation were only observed in case of PWM stimulation. In early postoperative period, the LPB cultures of patients did not respond to PWM and were not sensitive to MP. In case of immunocorrection with MP in postoperative period, a noticeable response to PWM was observed in vitro on the 8th day, after the operation, whereas sensitivity to MP in vitro was not observed.

[Various aspects of the status of humoral immunity in patients after surgical correction of rheumatic heart defects under artificial circulation]. / Nekotorye aspekty sostoianiia gumoral'nogo immuniteta u bol'nykh posle khirurgicheskoi korrektsii revmaticheskikh porokov serdtsa v usloviiakh iskusstvennogo krovoobrashcheniia.

The serum concentrations of immunoglobulins A, M, and G were studied in 70 patients with rheumatic heart diseases and in 72 patients with spontaneous and pokeweed mitogen-induced production of these immunoglobulins and mononuclear peripheral blood cells. The investigations were done before and 1-2 and 7-8 days after surgery. Some patients received myelopid in the early postoperative period in addition to the conventional methods of therapy. With high serum IgA, IgM, and IgG levels, reduced humoral immunity was noted. Within the first two days after the operation, the capability of cells to produce IgA and IgG in response to pokeweed mitogen stimulation was lost, the induced IgM production was reduced considerably, and the serum IgA and IgM levels fell significantly. Eight days after surgery, the immune response was partially recovered. Myelopid facilitates complete restoration of humoral immunity and reduces the incidence of postoperative pneumonia more than threefold.